Process for the resolution of 1-aminoindanes

Details Process for the resolution of 1-aminoindanes Process for the resolution of 1-aminoindanes

C - Chemistry, Metallurgy

07

C

260/476.1, 260/4

C07C 211/42 (2006.01) C07C 215/44 (2006.01) C07C 217/48 (2006.01) C07H 19/16 (2006.01)

Patent

CA 1282080

ABSTRACT An improved process for the resolution of 1-aminoindanes into the R-isomer on a large scale is described. The resolving agent used in the process is R-N-acetyl-3,4-dimethoxyphenylalanine. The process is of intermediates in the production of certain adenosines and their pharmaceutically acceptable acid addition salts. The adenosines have desirable central nervous system and cardiovascular activities such as antipsychotic, sedative, antihypertensive, and antianginal.

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