Process for the resolution of a 4-aryl-2-oxopyrrolidine-3-...

Details Process for the resolution of a 4-aryl-2-oxopyrrolidine-3-... Process for the resolution of a 4-aryl-2-oxopyrrolidine-3-...

C - Chemistry, Metallurgy

12

P

195/131, 260/324

C12P 17/10 (2006.01) C07D 207/277 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2026862

Abstract of the Disclosure An enzymatic process employing pancreatin or choelsterol esterase for resolution of racemates of 4-aryl- 2-oxo-pyrrolidine-3-carboxylic acid esters of general formula I Image (I), in which X represents a carbon-carbon bond or an oxygen atom, R1 means a hydrocarbon radical optionally substituted by hydroxy groups, oxo groups and/or halogen atoms and/or interrupted by nitrogen atoms with at most 16 carbon atoms, R2 symbolizes an alkyl group with up to 4 carbon atoms and R3 represents an alkyl group with at most 6 carbon atoms is described.

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