C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/317, 530/5.0
C07D 209/52 (2006.01) C07D 209/42 (2006.01) C07D 209/54 (2006.01) C07K 5/02 (2006.01)
Patent
CA 1283249
Abstract of the disclosure: The invention relates to a process for resolving racemic mixtures of bicyclic imino-.alpha.-carboxylic esters into the components by crystallization of diastereomeric salts, which comprises preparing the salts of the racemic esters with optically active N-acylated R- or S-amino- carboxylic acids which contain a phenyl nucleus, recrystal- lizing then from an organic solvent, decomposing the precipitated, optically homogeneous diastereomeric salts in a manner known per se, and isolating the enantiomers and, where appropriate, converting the latter into the free acids by hydrolysis in a manner known per se. The inven tion also relates to compounds of the formulae Ia and Ib indicated in the description, to diastereomeric salts of these compounds,and to a process for the preparation of optically pure compounds of the formula Image in which two of the radicals A, B1, B2 and C form a carbon chain and the others denote hydrogen, and r, R1, R2, X, Y and Z have the indicated meanings, which comprises reacting, in the presence of a condensing agent or, where appropriate, as the active esters, optically pure compounds of the indicated formulae Ia or Ib with optically pure compounds of the indicated formula III, eliminating the radical R by hydrogenolysis or hydrolysis and, where appropriate, con- verting the resulting optically pure compounds into physio- logically tolerated salts.
446349
Geiger Rolf
Henning Rainer
Langner Dietrich
Teetz Volker
Urbach Hansjorg
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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