Process for the resolution of tramadol

Details Process for the resolution of tramadol Process for the resolution of tramadol

C - Chemistry, Metallurgy

07

C

C07C 213/10 (2006.01) C07C 217/74 (2006.01)

Patent

CA 2353549

A process for preparing a substantially single enantiomer of tramadol, or a pharmaceutically-acceptable salt thereof, proceeds by means of a classical salt resolution using a substantially single enantiomer of o,o-di-p- toluoyltartaric acid as a resolving agent.

La présente invention concerne un procédé de préparation d'un énantiomère de tramadol sensiblement unique, ou d'un sel pharmaceutiquement acceptable de ce dernier, obtenu au moyen d'une résolution de sel classique par utilisation d'un énantiomère sensiblement unique d'un acide de o,o-di-p-toluoyltartrique comme agent de résolution.

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