Process for the selective side chain degradation of steroid...

Details Process for the selective side chain degradation of steroid... Process for the selective side chain degradation of steroid...

C - Chemistry, Metallurgy

12

P

195/19, 195/34.3

C12P 33/16 (2006.01) C07J 9/00 (2006.01) C12N 1/00 (2006.01) C12N 15/01 (2006.01) C12P 33/00 (2006.01)

Patent

CA 1141313

A B S T R A C t For the production of 17-C-steroid-.alpha.-propionic acid compounds by microbial side chain degradation on 17-C-side chain steroid sub- strates wild strain microorganisms selected in predetermined d manner are subjected to a multi-stage mutation and selection. The resultant mutant strains are capable of supplying the desired compounds, e.g. a-4 BNC and/or A-1,4 BNC in high yields even in the absence of inhib- itors arresting the growth and/or degradation of the steroid ring. Wild strains and mutants particularly suitable, and their choice, pro- duction and use, are described.

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