Process for the separation of antifactor viii:c antibodies,...

Details Process for the separation of antifactor viii:c antibodies,... Process for the separation of antifactor viii:c antibodies,...

A - Human Necessities

61

K

167/139

A61K 39/395 (2006.01) A61K 35/16 (2006.01) A61M 1/36 (2006.01)

Patent

CA 1288046

- 22 - ABSTRACT OF THE DISCLOSURE The process for the separation of antiVIII:C antibodies present in a liquid consists of contacting said liquid with a solid support constituted by a polymer or a copolymer having in its chain substitutable groups, whereof at least part is substituted by groups having an affinity for antiVIII:C antibodies and a selectivity for antiVIII:C antibodies compared with other immunoglobulins and then separating the liquid from the support on which have been adsorbed the antiVIII:C antibodies. Preferably use is made of polystyrene, to which have been fixed groups -SO3Na and -SO2Glu, -SO2Threo, -SO2OHPro or SO2Lys. These supports can be used for ex-vivo purification in the column of the blood plasma of a type A hemophiliac.

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