Process for the stereoselective preparation of...

Details Process for the stereoselective preparation of... Process for the stereoselective preparation of...

C - Chemistry, Metallurgy

07

D

C07D 295/192 (2006.01) A61K 31/40 (2006.01) A61K 31/495 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2623350

The present invention provides a compounds the formula (IV): and methods for producing an .alpha.-(phenoxy)phenylacetic acid compound of the formula: wherein R1 is a member selected from the group consisting of: each R2 is a member independently selected from the group consisting of (C1- C4)alkyl, halo, (C1-C4)haloalkyl, amino, (C1-C4 aminoalkyl, amido, (C1- C4)amidoalkyl, (C1-C4)sulfonylalkyl, (C1-C4)sulfamylalkyl, (C1-C4)allcoxy, (C1- C4)heteroalkyl, carboxy and nitro; the subscript n is 1 when R1 has the formula (a) or (b) and 2 when R1 has the formula (c) or (d); the subscript m is an integer of from O to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R1; and compounds .

L'invention concerne des composés représentés par la formule (IV) ainsi que des méthodes permettant de produire un composé acide a-(phénoxy)phénylacétique représenté par la formule (I), dans laquelle R1 représente un élément choisi dans le groupe constitué de (a), (b), (c), (d). Chaque R2 est un élément choisi indépendamment dans le groupe constitué de (C1- C4)alkyle, halo, (C1-C4)haloalkyle, amino, (C1-C4 aminoalkyle, amido, (C1-C4)amidoalkyle, (C1-C4)sulfonylalkyle, (C1-C4)sulfamylalkyle, (C1-C4)alcoxy, (C1- C4)hétéroalkyle, carboxy et nitro ; l'indice n vaut 1 lorsque R1 est représenté par la formule (a) ou (b) et 2 lorsque R1 est représenté par la formule (c) ou (d) ; l'indice m vaut un entier de 0 à 3 ; * représente un carbone enrichi dans une configuration stéréoisomère ; et la ligne ondulée représente le point d'attache de R1; ainsi que des composés.

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