C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/08 (2006.01) C07D 471/20 (2006.01)
Patent
CA 2731895
The present invention relates to the stereoselective production of compounds of the general formula (I) and salts thereof, in particular physiologically compatible salts thereof containing inorganic or organic acids and bases and having valuable pharmacological properties, in particular an inhibiting effect on the signal transduction mediated by tyrosine kinases, use thereof in the treatment of illnesses, in particular tumor diseases and benign prostate hyperplasia (BPH), diseases of the lungs and respiratory tracts.
La présente invention concerne un procédé pour produire de manière stéréosélective des composés de formule générale (I) et leurs sels, notamment leurs sels physiologiquement acceptables, avec des acides et des bases organiques ou inorganiques, qui présentent des propriétés pharmacologiques intéressantes, en particulier une action inhibitrice sur la transduction du signal fournie par les tyrosine kinases, leur utilisation pour traiter des maladies, notamment des maladies tumorales ainsi que lhyperplasie bénigne de la prostate (HBP), des maladies du poumon et des voies respiratoires.
Braith Stefan
Daeubler Juergen
Huchler Guenther
Ostermeier Markus
Pfrengle Waldemar
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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