C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 45/00 (2006.01) C07C 49/84 (2006.01)
Patent
CA 2573115
A new process for the preparation of 4-trifluoromethylvalerophenone is described. The process described is a three step process comprising the synthesis of organomagnesium specie, coupling reaction between the of organomagnesiurn specie and trifluoromethylbenzonitrile or trifluoromethylbenzoyl chloride and preferably a purification of the product obtained in suitable reaction conditions. In the process an extraction phase of the final product is not required.
La présente invention concerne un nouveau processus de préparation de 4-trifluorométhylevalérophénone. Ce processus est un processus en trois étapes comprenant la synthèse d'espèce chimique organomagnesium, le couplage de réaction entre l'espèce chimique organomagnesium et le chlorure trifluorométhylebenzonitrile ou trifluorométhylebenzoyl et, de préférence une purification du produit obtenu dans des conditions de réaction convenables. Dans ce processus une phase d'extraction du produit final n'est pas requise.
Castellin Andrea
Gonzalez Trueba Guadalupe
Gregori Luca
Nicole' Andrea
Rubello Albino
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Lundbeck Pharmaceuticals Italy S.p.a.
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