Process for the synthesis of...

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C - Chemistry, Metallurgy

07

D

C07D 265/32 (2006.01)

Patent

CA 2342213

The present invention is concerned with a novel process for the preparation of N-benzyl-3-(4-fluorophenyl)-1,4-oxazin-2-one of formula (5). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity, in particular, as substance P (neurokinin-1) receptor antagonists.

La présente invention concerne un nouveau procédé de préparation de N-benzyl-3-(4-fluorophényl)-1,4-oxazin-2-one de la formule (5). Ce composé est utile, en tant qu'intermédiaire, dans la synthèse de composés possédant une activité pharmacologique, notamment comme antagonistes du récepteur de la substance P (neurokinine 1).

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