Process for the synthesis of 2-aminothiazole compounds as...

Details Process for the synthesis of 2-aminothiazole compounds as... Process for the synthesis of 2-aminothiazole compounds as...

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01)

Patent

CA 2677586

The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula (I) which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.

Cette invention se rapporte à un procédé industriel permettant de préparer des composés pharmaceutiques de formule (I) qui sont utilisés comme inhibiteurs de certaines tyrosine kinases et plus particulièrement comme inhibiteurs de c-kit et de bcr-abl. Les groupes R1 et R2, identiques ou différents, représentent chacun un atome d'hydrogène, un atome d'halogène, un groupe alkyle, alcoxy, trifluorométhyle, amino, alkylamino, dialkylamino, un groupe de solubilisation; m vaut de 0 à 5 et n vaut de 0 à 4; le groupe R3 représente un groupe aryle ou hétéroaryle comme décrit dans les revendications.

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