C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/24 (2006.01)
Patent
CA 2584831
The present invention is directed to processes for the preparation of 4-(3- methanesulfonyl-phenyl)-1-N-propylpiperidine (I) or a pharmaceutically acceptable salt thereof, which comprises: oxidizing a sulfide of the formula (II): with a catalytic oxidizing agent and an oxidant; to give a compound of the formula (III): followed by catalytic reduction of the compound of the formula (III).
La présente invention concerne des procédés destinés à la préparation de 4-(3-méthanesulfonyl-phényl)-1-N-propypipéridine (I) ou d'un sel pharmaceutiquement acceptable de ce composé. Ces procédés consistent à oxyder un sulfure de formule (II) avec un agent oxydant catalytique et un oxydant en vue de l'obtention d'un composé de formule (III), puis à opérer la réduction catalytique du composé de formule (III).
Desmond Richard
Devine Paul N.
Gauthier Donald R.
Mccarthy Tetrault Llp
Neurosearch Sweden Ab
Sverige Nsab Filial Af Neurosearch Sweden Ab
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