C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 29/143 (2006.01) C07C 17/12 (2006.01) C07C 29/88 (2006.01) C07C 33/46 (2006.01) C07C 45/00 (2006.01) C07F 15/00 (2006.01) C07F 17/02 (2006.01)
Patent
CA 2376598
The present invention is concerned with a process for the preparation of (R)-1- (3,5-bis(trifluoromethyl)phenyl)ethanol by asymmetric transfer hydrogenation of 3,5-bis(trifluoromethyl)acetophenone using a rhodium of ruthenium catalyst and a ligand in the presence of an alcohol. Also claimed are specific complexes of (S,R)-1-amino-2-hydroxyindane with rhodium and ruthenium as well as a process for purifying (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethanol by means of its complex with 1,4-diazabicyclo[2.2.2]octane and the 2:1 complex of (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethanol with 1,4- diazabicyclo[2.2.2]octane.
La présente invention concerne un procédé de préparation de (R)-1-(3,5-bis(trifluorométhyle)phényle)éthanol par hydrogénation à transfert asymétrique de 3,5-bis(trifluorométhyle)acétophénone au moyen d'un catalyseur de rhodium ou de ruthénium et d'un ligand en présence d'alcool. L'invention concerne également des complexes de (S,R)-1-amino-2-hydroxyindane avec du rhodium et du ruthénium ainsi qu'un procédé de purification de (R)-1-(3, 5-bis (trifluorméthyle)phényle)éthanol au moyen de son complexe avec 1,4-diazobicyclo[2.2.2]octane et le complexe 2:1 de (R)-1-(3,5-bis(trifluorométhyle)phényle)éthanol avec 1,4-diazabicyclo[2.2.2]octane.
Devine Paul
Hansen Karl
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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