Process for the synthesis of 9.alpha.-hydroxy-steroids

C - Chemistry – Metallurgy – 07 – J

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C07J 21/00 (2006.01)

Patent

CA 2689422

The present invention relates to a novel selective synthesis of 9.alpha.-hydroxy-steroid derivatives of the general formula (I) (I) - wherein the meaning of -A-A'- is -CH2-CH2- or -CH=CH- group - by the bioconversion of compounds of the general formula (II) (II) wherein the meaning of -A-A'- is -CH2-CH2- or -CH=CH- group - by using Nocardia farcinica bacterium strain, deposition number of which is NCAIM (P) - B 001342, as hydroxylating microorganism in the bioconversion.

La présente invention concerne une nouvelle synthèse sélective de dérivés de 9.alpha.-hydroxy-stéroïde de formule générale (I) (I), dans laquelle -A-A'- représente un groupe -CH2-CH2- ou -CH=CH-, par la bioconversion de composés de formule générale (II) (II), dans laquelle -A-A'- représente un groupe -CH2-CH2- ou -CH=CH-, en utilisant une souche de bactérie Nocardia farcinica, dont le numéro de dépôt est NCAIM (P) - B 001342, en tant que micro-organisme hydroxylant dans la bioconversion.

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