Process for the synthesis of a peptide having a trp residue

Details Process for the synthesis of a peptide having a trp residue Process for the synthesis of a peptide having a trp residue

C - Chemistry, Metallurgy

07

K

C07K 1/04 (2006.01) C07K 1/06 (2006.01) C07K 7/23 (2006.01)

Patent

CA 2432708

A process for the solid phase synthesis of a peptide having at least one thyptophan residue, wherein said method comprises temporarily protecting the indole ring of said tryptophan residue with a side chain protecting group which is labile to a base wherein said protecting group is removed during cleavage of said peptide from the solid support.

L'invention concerne un procédé de synthèse en phase solide d'un peptide comportant au moins un résidu de tryptophane (Try), ledit procédé consistant à protéger temporairement le noyau indole dudit résidu de tryptophane au moyen d'un groupe protecteur de chaînes latérales qui est labile en milieu basique, ledit groupe protecteur étant retiré du support solide au cours du clivage dudit peptide.

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