Process for the synthesis of (aib8,35)hglp-1(7-36)-nh2

Details Process for the synthesis of (aib8,35)hglp-1(7-36)-nh2 Process for the synthesis of (aib8,35)hglp-1(7-36)-nh2

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01) A61K 38/26 (2006.01) C07K 1/04 (2006.01) C07K 1/06 (2006.01)

Patent

CA 2737770

The present invention relates to a process for the large-scale synthesis of (Aib8,35)hGLP-1(7-36)-NH2 (SEQ ED NO:2), i.e., His-Aib-Glu-Gly-Thr-Phe-Thr-Ser- Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gb-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val- Lys-Aib-Arg-NH2 (SEQ ID NO:2), which comprises solid-phase Fmoc-chemistry.

La présente invention porte sur un processus de synthèse à grande échelle de (Aib8,35)hGLP-l(7-36)-NH2 (SEQ ID N°:2), i.e., His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gb-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg-NH2 (SEQ ID N°:2), qui comprend une chimie de Fmoc en phase solide.

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