Process for the synthesis of amikacin

Details Process for the synthesis of amikacin Process for the synthesis of amikacin

C - Chemistry, Metallurgy

07

H

260/230.5

C07H 15/234 (2006.01) C07H 15/236 (2006.01)

Patent

CA 1296331

ABSTRACT A novel process for the synthesis of amikacin starting from kanamycin A protected at the positions 3 and 6' is described comprising the reaction of the latter with a salt of a bivalent metal cation selected among zinc, nickel, iron, cobalt, manganese, copper and cadmium in the presence of water as the solvent or co-solvent followed by the in situ reaction of the resulting complex with a reactive derivative of L-amino-2-hydroxy- butyric acid, removal of the metal cation of the protecting groups and purification of the thus obtained raw product. The acylation under these conditions is extremely selective.

520035

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