Process for the synthesis of amikacin

Details Process for the synthesis of amikacin Process for the synthesis of amikacin

C - Chemistry, Metallurgy

07

H

260/230.5

C07H 15/23 (2006.01) C07H 15/236 (2006.01)

Patent

CA 1324375

ABSTRACT In the synthesis of amikacin, having the formula: Image (I) by acylation of a diprotected derivative of kanamycin A with a reactive derivative of L-(-)-4-amino-2-hydroxybutyric acid, the selection of the reaction solvent and of the pH conditions permit the industrial economicity and the synthesis yield to be improved.

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