Process for the synthesis of chloropurine intermediates

Details Process for the synthesis of chloropurine intermediates Process for the synthesis of chloropurine intermediates

C - Chemistry, Metallurgy

07

D

C07D 473/40 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2306958

The present invention relates to a process for the preparation of a carbocyclic purine nucleoside analogue of formula (I), its salts and pharmaceutically acceptable derivatives thereof which comprises hydrolysing a compound of formula (IV) wherein P is a protecting group, in the presence of an acid, condensing the product of formula (V) formed in situ in the presence of a base with a compound of formula (VI) followed by in situ ring closure of the resulting intermediate.

La présente invention concerne un procédé permettant de préparer un analogue d'un nucléoside de purine carbocyclique de formule (I), les sels de ce dernier et des dérivés pharmaceutiquement acceptables de ce dernier: lequel procédé est caractérisé en ce que l'on hydrolyse, en présence d'un acide, un composé de formule (IV): dans laquelle P est un groupe protecteur, on condense le produit de formule (V): formé in situ en présence d'une base avec un composé de formule (VI): et l'on effectue in situ la fermeture du cycle du composé intermédiaire obtenu.

Affiliated with

Also associated with

Rating

Process for the synthesis of chloropurine intermediates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the synthesis of chloropurine intermediates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the synthesis of chloropurine intermediates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1976097