Process for the synthesis of diricinoleylphosphatidylcholine

Details Process for the synthesis of diricinoleylphosphatidylcholine Process for the synthesis of diricinoleylphosphatidylcholine

C - Chemistry, Metallurgy

07

F

C07F 7/10 (2006.01) C07F 9/10 (2006.01) C12P 7/64 (2006.01)

Patent

CA 2279221

Diricinoleylphosphatidylcholine (I) in an optically active form is obtained with good yields and a high purity by means of a process which comprises: a) esterifying the terminal carboxylic group of ricinoleic acid (III) with an alcohol having from 1 to 4 carbon atoms to give the corresponding ester having formula (IV); b) protecting the hydroxylic group of the ester of ricinoleic acid (IV) with a protecting group removable under bland operating conditions and isolating the ester of ricinoleic acid of which the hydroxylic group (V) is protected; c) hydrolyzing the ester of ricinoleic acid of which the hydroxylic group (V) is protected and isolating the ricinoleic acid of which the hydroxylic group (VI) is protected; d) acylating L-.alpha.-glycerophosphatidylcholine (II) with an imidazolic or triazolic derivative of the compound having formula (VI) and isolating the diricinoleylphosphatidylcraoline of which the hydroxylic group (VII) is protected; e) removing the protecting group from the hydroxylic group of the compound having formula (VII); and finally f) recovering and purifying the compound having formula (I) by means of chromatography.

Affiliated with

Also associated with

Rating

Process for the synthesis of diricinoleylphosphatidylcholine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the synthesis of diricinoleylphosphatidylcholine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the synthesis of diricinoleylphosphatidylcholine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2056894