Process for the synthesis of e1 activating enzyme inhibitors

Details Process for the synthesis of e1 activating enzyme inhibitors Process for the synthesis of e1 activating enzyme inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07C 215/44 (2006.01) C07C 217/52 (2006.01) C07C 219/24 (2006.01)

Patent

CA 2695193

The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1S, 2S, 4R)-2-hydroxy-4-{7H-pyrrolo[2/3-d]pyrimidin-7- yl}cyclopentyl)methyl sulfamates, which are El activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with El activity.

La présente invention concerne des procédés et des intermédiaires de synthèse permettant la synthèse de ((1S, 2S, 4R)-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)méthylsulfamates substitués en position 4, qui sont des inhibiteurs de l'enzyme d'activation E1, et sont utiles pour le traitement de troubles de la prolifération cellulaire, en particulier le cancer, et d'autres troubles associés à l'activité d'E1.

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