C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 57/60 (2006.01) C07C 69/65 (2006.01) C07D 205/08 (2006.01) C07D 263/26 (2006.01)
Patent
CA 2731924
The present invention discloses novel and useful intermediates for the synthesis of ezetimibe (EZT), which intermediates share a characteristic Z-isomeric structure. Based on Z-5-(4-fluorophenyl)- pent-4-enoic acid, and proceeding the synthesis through further Z-intermediates, a total synthesis is presented to obtained final ezetimibe in high yields.
La présente invention concerne de nouveaux intermédiaires utiles pour la synthèse dézétimibe (EZT), lesdits intermédiaires ayant une structure disomérie Z caractéristique commune. Le procédé de synthèse est basé sur lacide Z-5-(4-fluorophényl)-pent-4-enoïque grâce à dautres intermédiaires Z, pour une synthèse totale permettant lobtention dézétimibe final à des rendements élevés.
Casar Zdenko
Gobec Stanislav
Kovac Andreja
Mravljak Janez
Sova Matej
Goudreau Gage Dubuc
Lek Pharmaceuticals D.d.
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