Process for the synthesis of hiv protease inhibitors

Details Process for the synthesis of hiv protease inhibitors Process for the synthesis of hiv protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 307/20 (2006.01)

Patent

CA 2324217

An improved process for the synthesis of (3S)-tetrahydro-3-furyl N-[(1S,2R)-3-(4-amino-N-isobutylbenzenesulphonamido)-1- benzyl-2- hydroxypropyl]carbamate comprising four steps from the compound of formula (A) and a novel intermediate thereto.

Cette invention se rapporte à un procédé amélioré servant à la synthèse de (3S)-tétrahydro-3-furyl-(N)-[(1S), (2R)-3-(4-amino-(N)-isobutylbenzènesulfonamido)-1-benzyl-2-hydroxpropyl] carbamate, ce procédé comprenant quatre étapes à partir du composé représenté par la formule (A), ainsi qu'à un nouvel intermédiaire de celui-ci.

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