Process for the synthesis of semi-synthetic...

Details Process for the synthesis of semi-synthetic... Process for the synthesis of semi-synthetic...

C - Chemistry, Metallurgy

08

B

C08B 37/10 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2114863

A process for the synthesis of semi-synthetic glycosaminoglycans of general formula III Image is described in which one of the saccharide units characteristic of glycosaminoglycans with heparin or heparan structure, more specifically that of .alpha.-L-iduronic-2-O-sulfate acid, has undergone a structural modification, entirely or in part, with transformation into .alpha.-L-galacturonic acid substituted in position 3 with nucleophilic radicalsof general formula II Image Said process is carried out by treating glycosaminoglycans with heparin or heparan structure by means of a nucleophilic reagent in alkaline medium.

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