Process for the synthesis of the levodopa

Details Process for the synthesis of the levodopa Process for the synthesis of the levodopa

C - Chemistry, Metallurgy

07

C

260/516.3, 260/5

C07C 229/36 (2006.01) C07C 227/34 (2006.01) C07C 237/20 (2006.01) C07C 255/26 (2006.01) C07C 255/43 (2006.01)

Patent

CA 1338672

New process for the synthesis of the levodopa, L-(-)-2- amino-3-(3,4-dihydroxyphenyl)propionic acid, drug used in the treatment of the Parkinson's disease. The process consists in resolving with (+)-camphorsulfonic acid, or with a salt thereof, the (+),(-)-2-amino-3-(3,4-dimethoxyphenyl)propionitrile, obtained from the 3,4-dimethoxyphenylacetaldehyde, and in the subsequent hydrolysis and demethylation, by means of concentrated solutions of haloid acids, of the (+)-2-amino- 3-(3,4-dimethoxyphenyl)propionitrile and of salts thereof.

605420

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