A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/282
A61K 31/00 (2006.01)
Patent
CA 2001946
72-013 PROCESS FOR THE TREATMENT OF THE SKIN TO ALLEVIATE SKIN DISEASES ARISING FROM CONTACT SENSITIZATION OR IRRITATION UTILIZING p-SUBSTITUTED PHENOXY ALKANOLS ABSTRACT OF THE DISCLOSURE Skin diseases are treated by topical application of p-substituted phenoxy alkanols having the structure: Image I in which: R1 substituted in ortho, meta or para position is selected from hydrogen, halogen, alkyl having from one to six carbon atoms, preferably para-chlorine or para-tertiary-butyl; and bivalent cycloalkylene condensed with the phenyl group at adjacent ring carbons thereof, such as in indane; R2 and R3 are hydrogen or hydroxyl and at least one of R2 and R3 is hydroxyl; and n1, n2 and n3 represent the number of CH2, CHR2 and CH2 groups, respectively, and are numbers within the range from 1 to 10. The topical application to the skin of these compounds jointly with an agent that causes irritation, inflammation or contact sensitization modifies and mitigates such irritation, inflammation and sensitization.
Berger Frank M.
Gowling Lafleur Henderson Llp
LandOfFree
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