C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/128.2
C12P 21/06 (2006.01) C07K 14/62 (2006.01)
Patent
CA 1339955
This specification describes a process for converting a human insulin precursor to human insulin, which comprises treating such human insulin precursor with trypsin and carboxypeptidase B in an aqueous medium containing per mole of human insulin precursor from about 0.1 to about 10 moles of one or more metal ions of those metals having Atomic Numbers 21 to 34, 39 to 52, 57 to 84, and 89 to 92.
548665
Frank Bruce Hill
Heiney Richard Eugene
Prouty Walter Francis
Walden Mark Robert
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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