Process (ii) for the preparation of powdered medicament

Details Process (ii) for the preparation of powdered medicament Process (ii) for the preparation of powdered medicament

A - Human Necessities

61

J

167/158, 167/165

A61J 3/02 (2006.01) A61K 9/16 (2006.01) A61K 9/72 (2006.01) B01J 2/00 (2006.01) B01J 2/20 (2006.01)

Patent

CA 2172055

According to the invention there is provided a method of treatment of a finely divided powdered medicament having a particle size smaller than 10 µm and poor flowing properties to form, in a controlled manner, agglomerates or pellets which are free flowing and which are capable of breaking down to provide the finely divided medicament, comprising the steps of agglomerating the powdered medicament having a particle size being smaller than 10 µm by feeding the material to a sieve, causing the finely divided powdered medicament to pass through the apertures of the sieve thereby obtaining agglomerates, spheronizing the resulting agglomerates in order to provide agglomerates which are more spherical, more dense and more compact than the agglomerates resulting from the agglomeration process in the sieve, and sizing the agglomerates to obtain a uniform size of the final product. According to the invention there is also provided an apparatus for carrying out the method.

Est décrit un procédé de traitement d'un médicament en poudre fine présentant une grosseur particulaire inférieure à 10 µm et des caractéristiques d'écoulement médiocres pour former, de manière contrôlée, des agglomérés ou des pastilles qui s'écoulent librement et qui peuvent se décomposer pour donner le médicament en poudre fine. Ce procédé consiste à agglomérer le médicament en poudre de la grosseur particulaire précitée, en acheminant la matière à un tamis, à la faire passer à travers les mailles du tamis pour obtenir des agglomérés, à sphéroniser les agglomérés résultants afin d'obtenir des agglomérés qui sont plus sphériques, plus denses et plus compacts que les agglomérés résultant du processus d'agglomération dans le tamis, et à calibrer les agglomérés pour obtenir une taille homogène du produit final. Est également décrit un appareil pour la mise en oeuvre du procédé.

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