Process improvement in the synthesis of...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 487/04 (2006.01)

Patent

CA 2191647

The invention is a process improvement for producing N-[3-(3-cyano- pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide which is useful as an anxiolytic, antiepileptic, sedative-hypnotic agent and skeletal muscle relaxant. The disclosed invention comprises reacting 3-dimethylamino-1-(3-N-ethyl-N-acetyl- aminophenyl)-2-propen-1-one or a suitable salt thereof with 3-aminopyrazole-4- carbonitrile or a suitable salt thereof in a mixture comprising water and acetic acid or a suitable salt thereof, rather than in acetic acid alone.

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