Process of converting taxanes into baccatin iii and...

Details Process of converting taxanes into baccatin iii and... Process of converting taxanes into baccatin iii and...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01)

Patent

CA 2142354

A process for the preparation of a compound of formula (II) where R1 = H or R1 = COCH3, comprising contacting a mixture containing at least one taxane compound having an ester linkage at the C-13 position with at least one borohydride reducing salt in a reaction solvent in the presence of a Lewis acid.

Méthode pour préparer un composé de formule (II), dans laquelle R1 = H ou R1 = COCH3, consistant à mettre en contact un mélange contenant au moins un taxane à liaison ester en position C-13, avec au moins un sel réducteur de type borohydrure, dans un solvant de réaction en présence d'un acide de Lewis.

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