G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/15 (2006.01) G06F 19/16 (2011.01) G01N 24/08 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2653517
The present invention provides a process of designing compounds which bind to a specific target molecule. The process includes the steps of a) identifying a first ligand to the target molecule using two-dimensional 15N/1H NMR correlation spectroscopy; b) identifying a second ligand to the target molecule using two-dimensional 15N/1H NMR correlation spectroscopy; c) forming a ternary complex by binding the first and second ligands to the target molecule; d) determining the three-dimensional structure of the ternary complex and thus the spatial orientation of the first and second ligands on the target molecule; and e) linking the first and second ligands to form the drug, wherein the spatial orientation of step (d) is maintained.
Fesik Stephen W.
Hajduk Philip J.
Olejniczak Edward T.
Abbott Laboratories
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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