C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/34 (2006.01)
Patent
CA 2674451
A process for preparing the d-threo isomer of methylphenidate hydrochloride which includes (i) resolving a racemic mixture of racemic threo-methylphenidate hydrochloride with a less than stoichiometric amount of tertiary amine base to obtain a methylphenidate - chiral acid salt, (ii) basifying the methylphenidate - chiral acid salt to obtain methylphenidate free base, and (iii) converting the methylphenidate free base into d-threo-methylphenidate hydrochloride
L'invention concerne un procédé de préparation de l'isomère d-thréo de l'hydrochlorure de méthylphénidate. Le procédé comprend les étapes consistant à : (i) séparer un mélange racémique d'hydrochlorure de thréo-méthylphénidate racémique avec une quantité inférieure à la quantité stoechiométrique d'une base amine tertiaire pour obtenir un sel acide chiral de méthylphénidate, (ii) basifier le sel acide chiral de méthylphénidate pour obtenir une base libre de méthylphénidate et (iii) transformer la base libre de méthylphénidate en hydrochlorure de d-thréo-méthylphénidate.
James E. Aldred Jr.
Ji Yu
Kalinin Alexei
Marren Thomas J.
Qiu Guofang
Archimica Inc.
Fetherstonhaugh & Co.
LandOfFree
Process of enantiomeric resolution of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process of enantiomeric resolution of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process of enantiomeric resolution of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1933908