C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/46 (2006.01) C07C 275/34 (2006.01) C07D 239/34 (2006.01)
Patent
CA 2530776
Disclosed is a process of making compounds of formula (I) wherein R1, R2, R3, R4 and Ra of formula (I) are defined herein. The product compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation. Also disclosed are intermediates useful in making such compounds.
La présente invention se rapporte à un procédé de fabrication de composés représentés par la formule (I), dans laquelle R¿1?, R¿2?, R¿3?, R¿4? et Ra de la formule (I) sont définis dans la description associée. Les composés produits inhibent la production de cytokines impliquées dans les processus inflammatoires et sont par conséquent utiles pour traiter des maladies et des troubles pathologiques associés à une inflammation. L'invention se rapporte également à des intermédiaires utiles pour la fabrication de ces composés.
Haddad Nizar
Senanayake Chris Hugh
Wei Xudong
Xu Jinghua
Yee Nathan
Boehringer Ingelheim Pharmaceuticals Inc.
Fetherstonhaugh & Co.
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