Process of making spirocycles and analogs thereof

Details Process of making spirocycles and analogs thereof Process of making spirocycles and analogs thereof

C - Chemistry, Metallurgy

07

D

C07D 491/107 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2164643

The present invention is directed to a process of making spirocycles of general structural formula (I), where R1 is selected from the group consisting of CO-CO1-3 alkyl, cyano, carboxy, carboxy C1-6 alkyl ester, carboxamide, C1-6 alkyl sulfinyl, C1-6 alkyl sulfonyl, C1-6 methanesulfonamide and halogen; R2 is selected from the group consisting of keto or alcohol, R3 is cyano, resulting in compounds which are Class III antiarrhythmic.

L'invention concerne un procédé de fabrication de spirocycles de formule structurelle générale (I), dans laquelle R1 est choisi dans le groupe comprenant alkyle CO-C1-3, cyano, carboxy, ester d'alkyle C1-6 de carboxy, carboxamide, sulfinyle d'alkyle C1-6, sulfonyle d'alkyle C1-6, méthanesulfonamide C1-6 et halogène; R2 est choisi dans le groupe comprenant céto ou alcool, R3 représente cyano. Ledit procédé permet de produire des composés antiarythmiques de Classe III.

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