Process of obtaining r,s-2,3,5,6-tetrahydro-6-phenyl-...

Details Process of obtaining r,s-2,3,5,6-tetrahydro-6-phenyl-... Process of obtaining r,s-2,3,5,6-tetrahydro-6-phenyl-...

C - Chemistry, Metallurgy

07

D

260/299

C07D 513/04 (2006.01) C07D 233/42 (2006.01)

Patent

CA 1100508

ABSTRACT OF THE DISCLOSURE: R,S-2,3,5,6-Tetrahydro-6-phenyl-imidazo(2,1-b)-thiazole (Tetramizole), of the formula: Image is obtained by reacting R,S)-.alpha.-(2-hydroxyethylaminomethyl)-benzyl- amine of the formula: Image with a compound of the formula: Image wherein R1 and R2 are identical and represent chlorine, or differ from one another, in which case R1 represents a loweralkoxy radical with 1 to 4 carbon atoms and R2 is SM, M representing sodium or potassium, to form R,S-1(2-Hydroxyethyl)-4-phenyl-imidazolidine-2- thione of the formula: Image which is subjected to a cyclodehydration to form R,S-2,3,5,6-tetra- hydro-6-phenyl-imidazo(2,1-b)-thiazole.

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