Process of obtaining r,s-2,3,5,6-tetrahydro-6-phenyl-...

Details Process of obtaining r,s-2,3,5,6-tetrahydro-6-phenyl-... Process of obtaining r,s-2,3,5,6-tetrahydro-6-phenyl-...

C - Chemistry, Metallurgy

07

D

260/299

C07D 513/04 (2006.01) C07D 233/42 (2006.01)

Patent

CA 1100507

ABSTRACT OF THE DISCLOSURE: R,S-2,3,5,6-Tetrahydro-6-phenyl-imidazo (2,1-b)- thiazole (Tetramisole), of the formula: Image is obtained by reacting R,S-.alpha.-(2-hydroxyethylaminomethyl)- benzylamine, of the formula: Image with carbon disulfide, to form R,S-N-(2-(2-hydroxyethylamino)- 1-phenylethyl)-amide of the dithiocarbonic acid, of the formula: Image which is cyclisized to R,S-1-(2-hydroxyethyl)-4-phenyl-imidazo- lidine-2-thione, of the formula: Image which on cyclodehydration yields R,S-2,3,5,6-tetrahydro-6- phenyl-imidazo(2,1-b)-thiazole.

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