Process of preparation of valacyclovir and relevant...

Details Process of preparation of valacyclovir and relevant... Process of preparation of valacyclovir and relevant...

C - Chemistry, Metallurgy

07

D

C07D 473/18 (2006.01) A61K 31/52 (2006.01) C07C 229/30 (2006.01)

Patent

CA 2261050

Process of preparation of valacyclovir (I), wherein derivative (IV) of acyclovir (I), in which the OH group of acyclovir at the omega position has been replaced by a good leaving group Z, is reacted with an alkaline salt of L- valine (V), to give intermediate (VI), which is successively hydrolyzed in an acid medium to give the corresponding salified valacyclovir (I-A), which may be optionally transformed into valacyclovir (I).

Cette invention concerne un procédé de préparation de valacyclovir (I), lequel fait appel à un dérivé (IV) d'acyclovir (I) dans lequel le groupe OH de l'acyclovir a été remplacé à la position oméga par un groupe partant Z viable. Ce procédé consiste à faire réagir le dérivé avec un sel alcalin de L-valine (V) de manière à obtenir un produit intermédiaire (VI). Ce produit peut ensuite être hydrolysé dans un milieu acide afin de produire le valacyclovir salifié (I-A) correspondant, ce dernier pouvant éventuellement être transformé en valacyclovir (I).

Affiliated with

Also associated with

Rating

Process of preparation of valacyclovir and relevant... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process of preparation of valacyclovir and relevant..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process of preparation of valacyclovir and relevant... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1475807