A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
260/540.95
A61K 31/17 (2006.01)
Patent
CA 1082223
ABSTRACT OF THE INVENTION A method of producing 1,3-bis(2-chloroethyl)-1- nitrosourea (BCNU) by nitrosation of 1,3-bis(2-chloroethyl)- urea utilizing as a nitrosating agent dinitrogen trioxide (N203) in molar excess of theoretical wherein the molar excess of N203 ranges from 10-200% and preferably from 10-20%. The nitrosation reaction is conventionally carried out in the cold From 0°C to -20°C and a non-aqueous solvent is utilized. The preferred non-aqueous solvent is of the chlorinated variety; i.e., methylene dichloride. Other preferred solvents include related halogenated compounds such as ethylene dichloride, nitro-compounds such as nitromethane, acetonitrile, and simple ethers such as ethyl ether. Other less preferred but operable compounds include esters such as ethyl acetate, simple ketones such as acetone, and chloroform. Solvents to be avoided are olefins, unsaturated ethers and other unsaturated compounds, amines, malonate esters, acid anhydrides, and solvents which would interact with the reactant N2O3 and the urea as well as the product nitrosourea.
226863
Sharp Donald E.
Yanko William H.
Goudreau Gage & Associates
United States Of America (government Of The) United States Depar
LandOfFree
Process of preparing 1,3-bis(2-chloroethyl)-1- nitrosourea does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process of preparing 1,3-bis(2-chloroethyl)-1- nitrosourea, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process of preparing 1,3-bis(2-chloroethyl)-1- nitrosourea will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1135234