Process of preparing a serum protein composition for...

A - Human Necessities – 61 – K

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A61K 35/16 (2006.01) A61K 37/02 (1980.01)

Patent

CA 1102694

TITLE PROCESS OF PREPARING A SERUM PROTEIN COMPOSITION FOR INTRAVENOUS APPLICATION INVENTOR Markus RADOWITZ ABSTRACT A process of preparing a serum protein composition for intravenous application or administration, in which process, starting from a human blood protein solution, a stablized, universally applicable preparation or composition is prepared which contains dissolved in an aqueous isotonic solution, such proteins characterized by performing the following steps: (a) fractionating the human blood plasma and removing coagulation factors; (b) recovering, during the said fractionation step, precipitates and supernatants at each differend fractionation step; (c) mixing and resolving of precipitates of the different fractionation steps, in which blood proteins, especially albumin and globulins, are preserved in a native form, said precipitates mixed and resolved in a chemically and physiologically adapted solvent, said solvent eventually containing also supernatants of the fractionation steps; (d) adjusting the mixture to a content of 11 - 60% albumin and - 89% globulin, (e) stabilizing, purifying and drawing off the preparation.

295681

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