C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 319/20 (2006.01) C07C 323/20 (2006.01)
Patent
CA 2512980
A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different from that on the parent probucol molecule but which maintains the two free hydroxyl groups) with a Grignard reagent or a lithium reagent that produces a magnesium bromide or lithium salt of probucol or the probucol derivative. The probucol compound anion anion is then reacted with an ester or ether forming compound.
Un probucol ou un dérivé de probucol peut être converti efficacement en un monoester ou un monoéther de probucol par réaction du porbucol contenant de l'hydroxyle libre ou un dérivé de celui-ci (ce qui signifie un composé de probucol ayant au moins un substituant différent de celui sur la molécule de probucol parente mais qui maintient les deux groupes hydroxyle libres) avec un réactif de Grignard ou un réactif au lithium produisant un sel bromure de magnésium ou lithium de probucol ou le dérivé de probucol. L'anion du composé de probucol est ensuite mis à réagir avec un composé formant ester ou éther.
Sikorski James A.
Weingarten M. David
Atherogenics Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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