Process of preparing physiologically active proteinaceous...

Details Process of preparing physiologically active proteinaceous... Process of preparing physiologically active proteinaceous...

C - Chemistry, Metallurgy

07

K

530/15.06, 195/3

C07K 3/26 (1990.01) A61K 37/36 (1990.01)

Patent

CA 1301680

Abstract of the disclosure: A membrane filter of 0.025 to 0.05 µ in pore size is treat- ed by passing the solution of a water-soluble high molecular substance such as albumin, dextran, polyvinylpyrrolidone, poly- sorbate 80, gelatin or the like through the membrane filter. Employing the filter thus treated, the solution of a physiologi- cally active substance of human origin such as human growth hormone, kallikrein, trypsin inhibitor, epidermal growth factor, leucocyte interferon etc. is filtered at high recovery rate of the active substance avoiding the adsorption of the active substance onto the filter. By the filtration, harmful viruses such as Creutzfeldt-Jacob disease pathogen which may exist in the phisiologically active substance can be removed.

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