Process of producing amorolfine

Details Process of producing amorolfine Process of producing amorolfine

C - Chemistry, Metallurgy

07

D

C07D 295/02 (2006.01)

Patent

CA 2601149

The present invention refers to an improved process of producing Amorolfine base, which is a compound of Formula (I) said process comprising the steps of: (i) contacting a compound of Formula (II) with a Friedel- Crafts catalyst at a temperature in the range of 20 to 30 ~C; and (ii) adding one equivalent of 2- halogeno-2- methylbutane, characterised in that the reaction mixture obtained in step (i) is cooled to a temperature between -40 to -60 ~C prior to step (ii).

La présente invention concerne un procédé de production amélioré d'une base d'amorolfine, qui est un composé représenté par la formule (I). Ledit procédé consiste (i) à mettre en contact un composé représenté par la formule (II) avec un catalyseur de Friedel-Crafts à une température de 20 à 30 °C; et (ii) à ajouter un équivalent de 2-halogéno-2- méthylbutane, se caractérisant en ce que le mélange de réaction obtenu au cours de l'étape (i) est refroidi à une température entre -40 et -60 °C avant l'étape (ii).

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