Process of producing bepromoline

Details Process of producing bepromoline Process of producing bepromoline

C - Chemistry, Metallurgy

07

D

C07D 295/02 (2006.01)

Patent

CA 2616160

The present invention refers to a process of manufacturing a compound of formula (Ia), said process comprising: (i) contacting a compound of formula (III) with a compound of formula (IV) in the presence of a palladium catalyst, methanol and hydrogen gas, said step (i) being conducted preferably under basic conditions with acetic acid added once the consumption of the hydrogen gas has ceased.

L'invention concerne un procédé de fabrication d'un composé de formule (Ia), qui consiste: (i) à mettre en contact un composé de formule (III) avec un composé de formule (IV) en présence d'un catalyseur au palladium, du méthanol et de l'hydrogène gazeux, l'étape (i) étant menée de préférence dans des conditions de base et l'acide acétique étant ajouté une fois la consommation de l'hydrogène gazeux terminée.

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