Process of protecting a 1,2-aminoalcohol for reductive...

Details Process of protecting a 1,2-aminoalcohol for reductive... Process of protecting a 1,2-aminoalcohol for reductive...

C - Chemistry, Metallurgy

07

F

C07F 7/10 (2006.01) C07C 213/02 (2006.01) C07C 213/08 (2006.01) C07C 217/62 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2248043

A process of protecting a 1,2- or 1,3-aminoalcohol for reductive amination coupling is provided. The alcohol is protected with trimethylsilyl chloride. Trimethylsilyl protected norepinephrine derivatives useful in the preparation of arbutamine are also provided.

Procédé de protection d'un 1,2- ou 1,3-aminoalcool destiné au couplage par amination réductrice. L'alcool est protégé par un chlorure de triméthylsilyle. L'invention concerne également des dérivés de noradrénaline protégés par triméthysilyle utiles dans la préparation d'arbutamine.

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