C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/64 (2006.01) C07K 1/16 (2006.01)
Patent
CA 2255062
A process for the chromatographic purification of cyclosporin A from a crude product containing cyclosporin complex by using a column filled with silica gel and by the application of multi-step chromatography with a column filled with normal phase silica gel and by a solvent mixture containing toluene as the major component is provided.
L'invention concerne un procédé de préparation chromatographique de cyclosporine A à partir d'un produit brut contenant un composé de cyclosporine, par utilisation d'une colonne remplie de gel de silice, et par application d'une chromatographie en plusieurs étapes avec une colonne remplie de gel de silice en phase normale et avec un mélange de solvants contenant du toluène comme composant principal.
Deak Lajos
Keri Vilmos
Mako Gyorgyne
Miskolczy Istvanne
Nagyne Arvai Edit
Biogal Gyogyszergyar Rt
G. Ronald Bell & Associates
Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag
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