A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/14 (2006.01)
Patent
CA 2452575
The present invention refers to a process to prepare a highly activated composite of one or more water-insoluble drugs, said process comprising the steps of: (a) subjecting said water-insoluble drug and a cross-linked polymer to co-grinding; (b) exposing the ground product of step a. to contact with water or water vapours. The resulting composite contains large amounts of drug in the easily soluble amorphous form, reduced amounts of drug in the nanocrystalline form, and is substantially free from practically insoluble drug crystals.
L'invention concerne un procédé permettant de préparer un composite hautement activé d'un ou de plusieurs médicaments insolubles dans l'eau. Ce procédé consiste : (a) à soumettre ce médicament insoluble dans l'eau et un polymère réticulé à un co-meulage ; (b) à exposer le produit meulé de l'étape (a) à un contact avec de l'eau ou des vapeurs d'eau. Le composite ainsi obtenu contient de grandes quantités de médicaments sous forme amorphe facilement soluble, de faibles quantités de médicaments sous forme nanocristalline et, de plus, ce composite est sensiblement dépourvu de médicaments sous forme de cristal pratiquement insolubles.
Bresciani Massimo
Dobetti Luca
Magarotto Lorenzo
Eurand Pharmaceuticals Ltd.
Marks & Clerk
LandOfFree
Process of thermodynamical activation of water-insoluble... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process of thermodynamical activation of water-insoluble..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process of thermodynamical activation of water-insoluble... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1512803