Process to create biomolecule arrays on metal surfaces

Details Process to create biomolecule arrays on metal surfaces Process to create biomolecule arrays on metal surfaces

G - Physics

01

N

G01N 33/543 (2006.01) B01J 19/00 (2006.01) C12M 1/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/553 (2006.01) G01N 33/566 (2006.01) G01N 37/00 (2006.01) G03F 9/00 (2006.01)

Patent

CA 2370261

Disclosed is a process to construct multi-component biomolecule or cellular arrays suitable for use in SPR imaging studies of large molecule, cellular/molecular and cell/cell interactions. The success of the procedure hinges on the use of a reversible protecting group to modify reversibly .omega.-functionalized alkanethiols self-assembled on metal substrates.

L'invention se rapporte à un procédé de fabrication de réseaux biomoléculaires et/ou moléculaires multi-composants, destinés à l'analyse d'imageries de détection par résonance plasmonique de surface(SPR) des interactions entre grosses molécules et des interactions cellulaires/moléculaires et cellulaires/cellulaires. Le succès d'une telle procédure repose sur l'utilisation d'un groupe de protection réversible qui permet de modifier de manière réversible les alcanethiols .omega.-fonctionnalisés assemblés automatiquement sur les substrats métalliques.

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