Process to produce 4-hydroxy-2-oxo-pyrane derivates useful...

Details Process to produce 4-hydroxy-2-oxo-pyrane derivates useful... Process to produce 4-hydroxy-2-oxo-pyrane derivates useful...

C - Chemistry, Metallurgy

07

D

C07D 309/32 (2006.01) C07C 45/30 (2006.01) C07C 47/277 (2006.01) C07C 59/48 (2006.01) C07C 201/16 (2006.01) C07C 205/56 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2300204

Disclosed is a novel process and novel intermediates to prepare [R-(R*,R*) ]-N-L3-[1-[5, 6-dihydro-4-hydroxy -2-oxo-6-(2-phenylethyl) -6-propyl-2H-pyran-3- yl]propyl]phenyl]-5- (trifluo- romethyl)-2- pyridinesulfonamide (XIX) which is a protease inhibitor useful in treating humans infected with the HIV virus.

L'invention concerne un nouveau procédé de préparation et de nouveaux produits intermédiaires permettant de préparer [R-(R*,R*) ]-N-[3-[1-[5, 6-dihydro-4-hydroxy -2-oxo-6-(2-phényléthyl) -6-propyl-2H-pyran-3- yl]propyl]phényl]-5- (trifluorométhyl)-2- pyridinesulfonamide (XIX), qui est un inhibiteur de protéase utile pour traiter les humains atteints du virus VIH.

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