C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/24 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2253259
A nucleic acid makes it possible to express a polypeptide with interleukin-16 activity in a procaryotic or eucaryotic host cell. Said nucleic acid codes for a polypeptide with the amino acid sequence SEQ ID NO:2 or for a SEQ ID NO:2 elongated at the N-terminus by an aspartic acid radical or shortened at the C- terminus by up to 8 amino acids. This nucleic acid is useful for producing an active IL-16 polypeptide.
L'acide nucléique décrit permet d'exprimer un polypeptide à activité d'interleukine-16 dans une cellule hôte procaryote ou eucaryote. Cet acide nucléique code un polypeptide caractérisé par la séquence d'acides aminés SEQ ID NO:2 ou par la SEQ ID NO:2 prolongée, l'extrémité terminale N, d'un radical acide aspartique ou raccourcie, à l'extrémité terminale C, de 8 acides aminés au maximum. Cet acide nucléique est utile pour produire un polypeptide d'IL-16 actif.
Baier Michael
Bannert Norbert
Kurth Reinhard
Lang Kurt
Werner Albrecht
Boehringer Mannheim Gmbh
Bundesrepublik Deutschland Vertreten Durch Den Bundesminister Fu
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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