C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/24 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2272846
A nucleic acid, which can be used to express a polypeptide with interleukin-16 activity in a prokaryotic or eukaryotic host cell, wherein the said nucleic acid codes for a polypeptide with the amino acid sequence SEQ ID NO:2 and/or a SEQ ID NO:2 N-terminally elongated by Ala-Ser or a form thereof which is shortened at its C-terminus by up to 8 amino acids, is suitable for producing an active IL-16 polypeptide.
L'invention porte sur un acide nucléique pouvant être utilisé pour exprimer un polypeptide ayant une activité de l'interleukine-16 dans une cellule hôte procaryote ou eucaryote. Ledit acide nucléique code pour un polypeptide avec la séquence aminoacide SEQ ID NO:2 et/ou une SEQ ID NO:2 prolongée en N-terminal par Ala-Ser ou une forme de Ala-Ser tronquée à son C-terminal par 1 à 8 aminoacides. L'acide nucléique de l'invention est approprié pour la production d'un polypeptide IL-16 actif.
Ambrosius Dorothee
Baier Michael
Kurth Reinhard
Lanzendorfer Martin
Werner Albrecht
Boehringer Mannheim Gmbh
Bundesrepublik Deutschland Vertreten Durch Den Bundesminister Fur Gesun Dheit
Marks & Clerk
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